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Introduction to systems biology : design principles of biological circuits

By: Alon, Uri.
Material type: materialTypeLabelBookSeries: Chapman and Hall/CRC mathematical & computational biology series: 10.Publisher: Boca Raton, FL : Chapman & Hall/CRC, ©2007Description: xvi, 301 p., [4] p. of plates : ill. (some col.) ; 26 cm.ISBN: 9781584886426.Subject(s): Computational biology | Biological systems -- Mathematical models | Systems Biology -- methodsOnline resources: Publisher description
Contents:
Introduction -- Transcription networks : basic concepts -- Autoregulation : a network motif -- The feed-forward loop network motif -- Temporal programs and the global structure of transcription networks -- Network motifs in developmental, signal transduction, and neuronal networks -- Robustness of protein circuits : the example of bacterial chemotaxis -- Robust patterning in development -- Kinetic proofreading -- Optimal gene circuit design -- Demand rules for gene regulation -- Epilogue : simplicity in biology -- The input function of a gene : Michaelis-Menten and Hill equations -- Multi-dimensional input functions -- Graph properties of transcription networks -- Cell-cell variability in gene expression.
Review: "An Introduction to Systems Biology: Design Principles of Biological Circuits builds a foundation for the intuitive understanding of general principles in biology. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models."--BOOK JACKET.
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Biology 570.285 ALO-I (Browse shelf) Available 002776
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Biology REF 570.285 ALO-I (Browse shelf) Not For Loan 001016

Systems and Synthetic Biology Winter

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Includes bibliographical references (p. 271-293) and index.

Ch. 1. Introduction -- Ch. 2. Transcription networks : basic concepts -- Ch. 3. Autoregulation : a network motif -- Ch. 4. The feed-forward loop network motif -- Ch. 5. Temporal programs and the global structure of transcription networks -- Ch. 6. Network motifs in developmental, signal transduction, and neuronal networks -- Ch. 7. Robustness of protein circuits : the example of bacterial chemotaxis -- Ch. 8. Robust patterning in development -- Ch. 9. Kinetic proofreading -- Ch. 10. Optimal gene circuit design -- Ch. 11. Demand rules for gene regulation -- Ch. 12. Epilogue : simplicity in biology -- App. A. The input function of a gene : Michaelis-Menten and Hill equations -- App. B. Multi-dimensional input functions -- App. C. Graph properties of transcription networks -- App. D. Cell-cell variability in gene expression.

"An Introduction to Systems Biology: Design Principles of Biological Circuits builds a foundation for the intuitive understanding of general principles in biology. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models."--BOOK JACKET.

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