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Alon, Uri

Introduction to systems biology : design principles of biological circuits Uri Alon. - Boca Raton, FL : Chapman & Hall/CRC, ©2007. - xvi, 301 p., [4] p. of plates : ill. (some col.) ; 26 cm. - Chapman & Hall/CRC mathematical and computational biology series ; 10 . - Chapman and Hall/CRC mathematical & computational biology series ; 10. .

Includes bibliographical references (p. 271-293) and index.

Introduction -- Transcription networks : basic concepts -- Autoregulation : a network motif -- The feed-forward loop network motif -- Temporal programs and the global structure of transcription networks -- Network motifs in developmental, signal transduction, and neuronal networks -- Robustness of protein circuits : the example of bacterial chemotaxis -- Robust patterning in development -- Kinetic proofreading -- Optimal gene circuit design -- Demand rules for gene regulation -- Epilogue : simplicity in biology -- The input function of a gene : Michaelis-Menten and Hill equations -- Multi-dimensional input functions -- Graph properties of transcription networks -- Cell-cell variability in gene expression. Ch. 1. Ch. 2. Ch. 3. Ch. 4. Ch. 5. Ch. 6. Ch. 7. Ch. 8. Ch. 9. Ch. 10. Ch. 11. Ch. 12. App. A. App. B. App. C. App. D.

"An Introduction to Systems Biology: Design Principles of Biological Circuits builds a foundation for the intuitive understanding of general principles in biology. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models."--BOOK JACKET.

9781584886426

2005056902

GBA614519 bnb

013380737 Uk


Computational biology.
Biological systems--Mathematical models.
Systems Biology--methods.

QH324.2 / .A46 2007

570.285 / ALO-I

QH324.2 / .A46 2007

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