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005 20220131130135.0
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010 _a 2014010851
020 _a9780815342441
040 _aDLC
_beng
_cDLC
_erda
_dDLC
042 _apcc
050 0 0 _aQH604.2
_b.L56 2015
082 0 0 _a571.7
_223
_bLIM-C
084 _aSCI000000
_aSCI008000
_aSCI017000
_2bisacsh
100 1 _aLim, Wendell
245 1 0 _aCell signaling :
_bprinciples and mechanisms
_cby Wendell Lim, Bruce Mayer and Tony Pawson.
260 _aNew York :
_bGarland Science,
_c©2015
300 _axvi, 400 p :
_bill. ;
_c28 cm.
_e1 poster (col. ill., both sides ; 71 x 53 cm)
505 0 _aIntroduction to cell signaling -- Principles and mechanisms of protein interactions -- Signaling enzymes and their allosteric regulation -- Role of post-translational modifications in signaling -- Subcellular localization of signaling molecules -- Second messengers: small signaling mediators -- Membranes, lipids, and enzymes that modify them -- Information transfer across the membrane -- Regulated protein degradation -- Modular architecture and evolution of signaling proteins -- Information processing by signaling devices and networks -- How cells make decisions -- Methods for studying signaling proteins and networks.
520 _a"Cell Signaling presents the principles and components that underlie all known signaling mechanisms. The book provides undergraduate and graduate biology students with the tools needed to make sense of the array of specific pathways used by the cell to communicate. As each concept is explained, numerous examples derived from known signaling mechanisms are used to illustrate the key points. It describes basic signaling mechanisms such as protein interactions, changes in enzyme activity, post-translational modifications, subcellular localization of signaling molecules, and small diffusible signaling mediators. The book also explores the components of signaling pathways and how they are "wired" into pathways and circuits that can process information. The book concludes with a unique chapter that presents extended examples in which specific problems encountered in signaling are introduced and solved, followed by a chapter on methods"--
650 0 _aCell interaction.
650 0 _aCellular signal transduction.
650 7 _aSCIENCE / General.
_2bisacsh
650 7 _aSCIENCE / Life Sciences / Biology / General.
_2bisacsh
650 7 _aSCIENCE / Life Sciences / Cytology.
_2bisacsh
700 1 _aMayer, Bruce
700 1 _aPawson, Tony
906 _a7
_bcbc
_corignew
_d1
_eecip
_f20
_gy-gencatlg
942 _2ddc
_cBK
999 _c156772
_d156772