Case Studies in Systems Biology [electronic resource] /

Introduction -- Guide to using the book -- Case studies.-Genetic regulatory network -- Synthetic biology switches -- Repressilator -- lac operon -- Bacterial physiology -- Bursting oscillators -- Glycolytic oscillations -- Signaling Pathways -- NF-kB signaling -- Chemotaxis -- Circadian Rhythms -- Cell cycle regulation -- Stem cells differentiation -- T-cells differentiation regulation -- Apoptosis regulation -- Future Trends in Systems Biology.

This book provides case studies that can be used in Systems Biology related classes. Each case study has the same structure which answers the following questions: What is the biological problem and why is it interesting? What are the relevant details with regard to cell physiology and molecular mechanisms? How are the details put together into a mathematical model? How is the model analyzed and simulated? What are the results of the model? How do they compare to the known facts of the cell physiology? Does the model make predictions? What can be done to extend the model? The book presents a summary of results and references to more relevant sources. The volume contains the classic collection of topics and studies that are well established yet novel in the systems biology field. .