Introduction to systems biology : design principles of biological circuits

Includes bibliographical references (p. 271-293) and index.

Ch. 1. Introduction -- Ch. 2. Transcription networks : basic concepts -- Ch. 3. Autoregulation : a network motif -- Ch. 4. The feed-forward loop network motif -- Ch. 5. Temporal programs and the global structure of transcription networks -- Ch. 6. Network motifs in developmental, signal transduction, and neuronal networks -- Ch. 7. Robustness of protein circuits : the example of bacterial chemotaxis -- Ch. 8. Robust patterning in development -- Ch. 9. Kinetic proofreading -- Ch. 10. Optimal gene circuit design -- Ch. 11. Demand rules for gene regulation -- Ch. 12. Epilogue : simplicity in biology -- App. A. The input function of a gene : Michaelis-Menten and Hill equations -- App. B. Multi-dimensional input functions -- App. C. Graph properties of transcription networks -- App. D. Cell-cell variability in gene expression.

"An Introduction to Systems Biology: Design Principles of Biological Circuits builds a foundation for the intuitive understanding of general principles in biology. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models."--BOOK JACKET.